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Cytochrome P450 4A

Cytochrome P450 4A

Cat no: C9095-16A

Supplier: United States Biological
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The Cytochrome P450 (P450) family of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as NADPH and P450 reductase. There are over 200 cDNA?s which encode P450 protein. Epoxygenases are those P450 proteins which metabolize AA to epoxyeicosatrienoic acid (EETs) and w-hydroxylases are those P450 proteins which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). 20-HETE is converted from AA by the 4A family of P450 proteins which includes at least 8 different, though closely related isoforms. 4A1, 4A2, & 4A3 have been cloned from liver, kidney and testis and have been detected in renal, hepatic & brain microvessels. Applications: Suitable for use in Western Blot and Immunohistochemistry (Fr). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C9095-16A
Reactivities: Rat, Feline, Rabbit
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Harder DR et al. J Vasc Res 32:79-92. 2. Ma YH et al. (1994) Am J Physiol 267:R579-89.
Additional info: Detects Cytochrome P450 4A from feline, rabbit and rat tissues. This antibody detects, to a lesser extent, isoforms 4A1 and 4A3. Species Crossreactivity: Crossreacts with Rabbit, Rat and Cat. Not yet tested in other species.

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