Home  >  Products  >  Cytokeratin 17, NT (Cytokeratin-17, CK 17, CK-17, K17, Keratin 17, Keratin-17, Keratin Type I Cytoskeletal 17, KRT 17, KRT17, KRT17 Protein, PC, PC2, PCHC1)
Cytokeratin 17, NT (Cytokeratin-17, CK 17, CK-17, K17, Keratin 17, Keratin-17, Keratin Type I Cytoskeletal 17, KRT 17, KRT17, KRT17 Protein, PC, PC2, PCHC1)

Cytokeratin 17, NT (Cytokeratin-17, CK 17, CK-17, K17, Keratin 17, Keratin-17, Keratin Type I Cytoskeletal 17, KRT 17, KRT17, KRT17 Protein, PC, PC2, PCHC1)

Cat no: C9097-16H

Supplier: United States Biological
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Among the members of the cytokeratin (CK) subfamily of intermediate filament (IF) proteins, CK 17 is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. It has an unusual expression pattern in normal and diseased states and has potential importance in tumor diagnosis. CK 17 synthesis seems to be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells" (1). It has been shown that CK 17 regulates cell growth through binding to the adaptor protein 14-3-3sigma. These findings reveal a new and unexpected role for the intermediate filament cytoskeleton in influencing cell growth and size by regulating protein synthesis (2). KRT17 is expressed in the nail bed, hair follicle, sebaceous glands, and other epidermal appendages (3). Applications: Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:10 Western Blot: 1:2000 Immunohistochemistry: 1:100-1:250 Immunocytochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C9097-16H
Reactivities: Human, Rat
Hosts: Rabbit
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50 mM Tris-Glycine (pH 7.4), 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Troyanovsky SM, et al. Eur J Cell Biol 59(1):127-37, 1992. 2. Kim S, et al. Nature 441(7091):362-5, 2006. 3. Covello SP, et al. Br J Dermatol 139(3):475-80, 1998.
Additional info: Recognizes human Cytokeratin 17. Species Crossreactivity: Rat.

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