Cytokeratin 19

Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40kD and 68kD and isoelectric pH between 4.9-7.8. The individual cytokeratin polypeptides are designated 1 to 20. Cytokeratin 1 has the highest molecular weight and the highest isoelectric pH, while cytokeratin 19 has the lowest molecular weight and a low isoelectric pH. The cytokeratins are divided into the type I and type II subgroups, the type II family members comprising the basic to neutral cytokeratins 1-8, while the type I group comprises the acidic cytokeratins 9-20. The cytokeratins are expressed in combinations which characterize the type of epithelium. Cytokeratin 19 is the smallest human cytokeratin (40kD) and is found in many simple and invariably in some non-keratinizing stratified squamous epithelia. All adenocarcinomas tested have been positive for cytokeratin 19.\n\nApplications: \nWestern blot \nImmunohistochemistry on frozen tissue sections. \nImmunocytochemistry \nFlow cytometry

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SPECIFICATIONS

Catalog Number

C9097-28C

Size

100ug

Applications

FC, ICC, IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in buffer with 0.1% sodium azide.

P Type

Mab

Purity

Purified IgG from culture supernatant.

References

1. Kwaspen,FH. et al., Reproducible and highly sensitive detection of the broad spectrum epithelial marker keratin 19 in routine cancer diagnosis. Histopathology (1997) 31:503

Additional Info

Reacts with glandular epithelial cells and most carcinomas. Does not react with hepatocytes and hepatocarcinoma. Recognizes human.