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Cytokeratin 19

Cat no: C9097-28E

Cytokeratin 19

Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40kD and 68kD and isoelectric pH between 4.9-7.8. The individual cytokeratin polypeptides are designated 1 to 20. Cytokeratin 1 has the highest molecular weight and the highest isoelectric pH, while cytokeratin 19 has the lowest molecular weight and a low isoelectric pH. The cytokeratins are divided into the type I and type II subgroups, the type II family members comprising the basic to neutral cytokeratins 1-8, while the type I group comprises the acidic cytokeratins 9-20. The cytokeratins are expressed in combinations which characterize the type of epithelium. Cytokeratin 19 is the smallest human cytokeratin (40kD) and is found in many simple and invariably in some non-keratinizing stratified squamous epithelia. All adenocarcinomas tested have been positive for cytokeratin 19.\n\nFusion Partner Px63 Ag 8.653 myeloma cell line \n\nSource Tissue culture supernatant \n\nApplications: Cytokeratin 19 positive detection distinguishes malignant from benign breast tumors. Suitable for use in Immunocytochemistry, Western blotting, Immunohistochemistry (staining frozen and paraffin wax embedded tissue sections after proteolytic enzyme digestion).

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SPECIFICATIONS

Catalog Number

C9097-28E

Size

100ug

Applications

ICC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as supernatant in PBS, 10mM sodium azide and 1mg/ml bovine serum albumin

P Type

Mab

Purity

Protein A affinity chromatography

Isotype

IgG1

References

Bartek, J. et al. Int. J. Cancer 36, 299

Additional Info

The antibody is specific to human cytokeratin 19 and is reactive with cells of epithelial origin.

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