Home  >  Products  >  Cytokeratin 19 (Cytokeratin-19, CK 19, CK19, CK-19, K1cs, Keratin 19, Keratin-19, K19, Keratin Type i 40kD, Keratin Type I Cytoskeletal 19, KRT19, MGC15366)
Cytokeratin 19 (Cytokeratin-19, CK 19, CK19, CK-19, K1cs, Keratin 19, Keratin-19, K19, Keratin Type i 40kD, Keratin Type I Cytoskeletal 19, KRT19, MGC15366)

Cytokeratin 19 (Cytokeratin-19, CK 19, CK19, CK-19, K1cs, Keratin 19, Keratin-19, K19, Keratin Type i 40kD, Keratin Type I Cytoskeletal 19, KRT19, MGC15366)

Cat no: C9097-27F

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
Cytokeratin polypeptide 19 (CK19) is a type I intermediate filament protein that is expressed in stratified and simple-type epithelia (1). Cytokeratins 8 and 19 concentrate at costameres of striated muscle and copurify with the dystrophin-glycoprotein complex, perhaps through the interaction of the cytokeratins with the actin-binding domain of dystrophin. Studies in COS-7 cells and in vitro showed that dystrophin binds directly and specifically to K19. Results show that dystrophin interacts through its ABD with CK19 specifically and are consistent with the idea that cytokeratins associate with dystrophin at the sarcolemma of striated muscle (2). CK19 is synthesized mainly in embryonic and adult simple epithelia, but has also been found in stratified epithelia as well. CK19 is the smallest known keratin and is remarkable in that, contrary to all other keratins, it does not have a designated partner for the formation of filaments, implying that regulation of its expression is different from other keratin-encoding genes (3). Applications: Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:20,000 Immunoprecipitation: 1:50 Immunohistochemistry: 1:250-1:500 Immunocytochemistry: 1:250-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C9097-27F
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50 mM Tris-Glycine (pH 7.4), 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Zhou X, et al. J Biol Chem 274(18):12861-6, 1999. 2. Stone MR, et al. Mol Biol Cell 16(9):4280-93, 2005. 3. Lussier M, et al. Gene 95(2):203-13, 1990.
Additional info: Recognizes human Cytokeratin 19.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave