Home  >  Products  >  Cytokeratin 19 (Keratin, Type I Cytoskeletal 19, Cytokeratin-19, CK-19, Keratin-19, K19, KRT19)
Cytokeratin 19 (Keratin, Type I Cytoskeletal 19, Cytokeratin-19, CK-19, Keratin-19, K19, KRT19)

Cytokeratin 19 (Keratin, Type I Cytoskeletal 19, Cytokeratin-19, CK-19, Keratin-19, K19, KRT19)

Cat no: C9097-24U

Supplier: United States Biological
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Among the cytoplasmic intermediate filaments (IF) proteins, keratins make up the largest family and are expressed specifically in epithelial cells in a cell-specific manner. Keratins include more than 20 unique gene products (termed K1-K20) that are divided into type I (K9-K20) and type II (K1-K8). Most epithelial cells express at least one type I and one type II keratin as their predominant IF protein complement in an epithelial cell-specific manner. Cytokeratin 19 (K19) is a type I intermediate filament protein that is expressed in stratified and simple-type epithelia. It is unique in that it has a very short 13aa tail domain. It possesses assembly properties and it may impart unique properties to the basal cells expressing it in skin epithelia. It maps to the 17q21.2 region oh human chromosome and has a molecular weight of 44,098D. It is expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Applications: Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:25-1:50 Optimal dilutions to be determined by the researcher. Positive Control: Skin Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C9097-24U
Reactivities: Human
Hosts: Mouse
Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Supernatant
References: 1. Bartek et al. J Cell Sci 75: 17, 1985. 2. Bartek et al. Histochem J 18: 565, 1986. 3. Bartek et al. Int J Cancer 36: 299, 1985. 4. Bartek et al. J Cancer Clin Oncol 22: 1441, 1986 5. Yuan et al. Apoptosis 3: 161, 1998. 6. Zhou et al. J Biol Chem 274: 12861, 1999. 7. Eckert et al. Proc. Natl. Acad. Sci. 85: 1114, 1988.
Additional info: Recognizes human Cytokeratin 19.

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