Home  >  Products  >  Cytokeratin 4 (Cytokeratin-4, CK 4, CK4, CK-4, CYK4, FLJ31692, Keratin 4, Keratin-4, Keratin Type II Cytoskeletal 4, K4, KRT4)
Cytokeratin 4 (Cytokeratin-4, CK 4, CK4, CK-4, CYK4, FLJ31692, Keratin 4, Keratin-4, Keratin Type II Cytoskeletal 4, K4, KRT4)

Cytokeratin 4 (Cytokeratin-4, CK 4, CK4, CK-4, CYK4, FLJ31692, Keratin 4, Keratin-4, Keratin Type II Cytoskeletal 4, K4, KRT4)

Cat no: C9097-35F

Supplier: United States Biological
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Intermediate filaments are protein polymers which, together with actin filaments and microtubules, form the cytoskeleton of cells. A number of human cytokeratins are expressed during the development of stratified epithelia from one-layered polar epithelia and continue to be expressed in several adult epithelial tissues. Expression of the genes encoding these stratification-related cytokeratins starts already in the basal cell layer and does not depend on vertical differentiation and detachment from the basal lamina. Results also show that simple epithelial and stratification-related cytokeratins can be coexpressed in basal cell layers of certain stratified epithelia such as esophagus (1). Mucous keratin CK4 is known to appear in epidermis under certain abnormal conditions. a dose-response study showed that the de novo appearance of K4 can be utilized as a sensitive test for retinoid bioactivity in epidermis in vivo (2). Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:2000 Immunohistochemistry: 1:100-1:250 Immunocytochemistry: 1:100-1:250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C9097-35F
Reactivities: Human, Rat
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50 mM Tris-Glycine (pH 7.4), 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1 Leube RE, et al. J Cell Biol 106(4):1249-61, 1988.2. Virtanen M, et al. J. Invest Dermatol 114(3): 487-93, 2000.
Additional info: Recogizes human Cytokeratin 4. Species Crossreactivity: Rat.

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