Home  >  Products  >  Cytokeratin 5 (Cytokeratin-5, CK 5, CK5, CK-5, 58kD Cytokeratin, DDD, EBS 2, EBS2, Keratin 5 (Epidermolysis Bullosa Simplex Dowling Meara/Kobner/Weber Cockayne Types), Keratin-5, Keratin Type II Cytoskeletal 5, K5, KRT5, KRT5A)
Cytokeratin 5 (Cytokeratin-5, CK 5, CK5, CK-5, 58kD Cytokeratin, DDD, EBS 2, EBS2, Keratin 5 (Epidermolysis Bullosa Simplex Dowling Meara/Kobner/Weber Cockayne Types), Keratin-5, Keratin Type II Cytoskeletal 5, K5, KRT5, KRT5A)

Cytokeratin 5 (Cytokeratin-5, CK 5, CK5, CK-5, 58kD Cytokeratin, DDD, EBS 2, EBS2, Keratin 5 (Epidermolysis Bullosa Simplex Dowling Meara/Kobner/Weber Cockayne Types), Keratin-5, Keratin Type II Cytoskeletal 5, K5, KRT5, KRT5A)

Cat no: C9097-37A2

Supplier: United States Biological
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Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. The mitotically active basal layers of most stratified squamous epithelia express 10 to 30% of their total protein as keratin. The two keratins specifically expressed in these cells are the type II keratin CK-5 and its corresponding partner, type I keratin CK-14, both of which are essential for the formation of 8-nm filaments (1). CK-5 and calretinin have been useful in different studies as immunohistochemical markers suggestive of mesothelioma, and their expression is analyzed for the histological differential diagnosis with adenocarcinomas, especially when confronting with metastatic tumors of unknown origin (2). Loss-of-function mutations in the keratin 5 gene (KRT5) affected family members and in six unrelated patients with Dowling-Degos disease (DDD), an autosomal dominant genodermatosis. This suggests a crucial role for keratins in the organization of cell adhesion, melanosome uptake, organelle transport, and nuclear anchorage (3). Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Immunohistochemistry (Paraffin): 1:50-1:100 Immunocytochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C9097-37A2
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
P type: Pab
Isotype: IgG
Purity: Supernatant
References: 1. Lersch R, et al. Mol Cell Biol. 9:3685-3697 (1989). 2. Cid Mouteira P, et al. Actas Urol Esp 30:367-371 (2006). 3. Betz RC, et al. Am J Hum Genet 78:510-519 (2006).
Additional info: Recogizes human Cytokeratin 5 at ~59kD.

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