Cytokeratin 6

The human type II Cytokeratin 6 (CK6) is expressed in a heterogeneous array of epithelial tissues under normal conditions, but is better known for its strong induction in stratified epithelia that feature an enhanced cell proliferation rate or abnormal differentiation. CK6a is clearly the dominant CK6 isoform in skin tissue samples and cultured epithelial cell lines and that the various isoforms are differentially regulated within and between epithelial tissue types. Our findings have direct implications for an understanding of the regulation and function of CK6 during hyperproliferation in stratified epithelia and the search for disease-causing mutations in CK6 sequences in the human population. keratins show a complex regulation with constitutive and inducible components in several stratified epithelia, including the oral mucosa and skin (1). CK6a show a complex regulation with constitutive and inducible components in several stratified epithelia, including the oral mucosa and skin. Studies demonstrate an essential structural role for CK6 isoforms in the oral mucosa, and implicate filiform papillae as being the major stress bearing structures in dorsal tongue epithelium (2).\n\nApplications:\nSuitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry: 1:250-500\nImmunocytochemistry: 1: 100-250\nFlow Cytometry: 1:30\nImmunoprecipitation: 1:30\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. \n\nManufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

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