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Cytokeratin 6 (Keratin 6, KRT6, K6irs, K6IRS2, KRT6IRS2, Cytokeratin-72, CK-72, KB35, Keratin Type II Cytoskeletal 72, Keratin 72, Keratin-72, K72, KRT72, MGC142246, Type-II Keratin Kb35, Type II Inner Root Sheath-specific Keratin-K6irs2)

Cat no: C9097-38A

Cytokeratin 6 (Keratin 6, KRT6, K6irs, K6IRS2, KRT6IRS2, Cytokeratin-72, CK-72, KB35, Keratin Type II Cytoskeletal 72, Keratin 72, Keratin-72, K72, KRT72, MGC142246, Type-II Keratin Kb35, Type II Inner Root Sheath-specific Keratin-K6irs2)

Among the cytoplasmic intermediate filaments (IF) proteins, keratins make up the largest family and are expressed specifically in epithelial cells in a cell-specific manner. Keratins include more than 20 unique gene products (termed K1-K20) that are divided into type I (K9-K20) and type II (K1-K8). The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. Keratin 6 is a type-II keratin. It exists in six different isomeric forms which associate with KRT16 and/or KRT17. Mutations in this gene have been associated with pachyonychia congenita. It maps to 12q12-q13 region of human chromosome. It is expressed in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia.\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (formalin fixed paraffin embedded): 1:25-1:75\nImmunohistochemistry: Frozen\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nSkin\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C9097-38A

Size

500ul

Applications

IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid, 0.05% sodium azide.

P Type

Mab

Purity

Purified

Isotype

IgG2a

References

1. Wetzels et al. Am J Pathol 138: 751, 1991.

Additional Info

Recognizes human Cytokeratin 6.

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