Among the cytoplasmic intermediate filaments (IF) proteins, keratins make up the largest family and are expressed specifically in epithelial cells in a cell-specific manner. Keratins include more than 20 unique gene products (termed K1-K20) that are divided into type I (K9-K20) and type II (K1-K8). Most epithelial cells express at least one type I and one type II keratin as their predominant IF protein complement in an epithelial cell-specific manner. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2 and the type II cytokeratins are clustered in a region of chromosome 12q12-q13. It maps to 6q25.1 region of human chromosome.
Applications:
Suitable for use in Immunohistochemistry . Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 1:75-1:200
Optimal dilutions to be determined by the researcher.
Positive Control:
Skin
Cellular Localization:
Cytoplasmic
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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