Home  >  Products  >  D-erythro-Dihydrosphingosine 1-phosphate ((2S,3R)-Dihydro-sphingosine 1-phosphate, Dihydro-S1P, dhS1P)

D-erythro-Dihydrosphingosine 1-phosphate ((2S,3R)-Dihydro-sphingosine 1-phosphate, Dihydro-S1P, dhS1P)

Cat no: 044721


Supplier: United States Biological
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Saturated analog of sphingosine 1-phosphate (1-SP1). Ligand for sphingosine 1-phosphate (S1P/EDG) receptors. Negative control for intracellular effects of sphingosine 1-phosphate. Induces chemotaxis. Antifibrotic. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 2 years after receipt when stored at -20 degrees C.
Catalogue number: 044721
Size: 1mg
Purity: >98% (NMR)
Alternative names: (2S,3R)-Dihydro-sphingosine 1-phosphate, Dihydro-S1P, dhS1P
References: Product Reference: ?Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival: J.R. van Brocklyn, et al.; J. Cell Biol. 142, 229 (1998) ?Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis: F. Wang, et al.; JBC 274, 35343 (1999) ?Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218: J.R. van Brocklyn, et al. JBC 274, 4626 (1999) ?Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels: Arthritis Rheum. 62, 2117 (2010) ?

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