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DAAM1 (Disheveled-associated Activator of Morphogenesis 1, KIAA0666)

DAAM1 (Disheveled-associated Activator of Morphogenesis 1, KIAA0666)

Cat no: D0875-01C

Supplier: United States Biological
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DAAM1 is a diaphanous-related formin first studied as a novel Dishevelled binding protein and shown to be crucial for the planar cell polarity pathway in Xenopus. DAM1, like other formins, directs nucleation and elongation of new actin filaments using its conserved formin-homology-2 (FH2) domain. It is a Rho-regulated formin implicated in neuronal development and regulation of gastrulation. It was identified as a binding protein of the Wnt receptor-associated protein Dishevelled. It also binds the GTP-bound RhoA and increases its GTP-bound form population in cells. It exists in an autoinhibited state via intramolecular interactions between its amino-terminal GBD and carboxyl-terminalDD domains. Structurally the protein includes a GTPase-binding domain (GBD), a diaphanous inhibitory domain (DID), and a coiled-coil region followed by the FH1, FH2 and C-terminal diaphanous auto-regulatory domain (DAD). In humans, theDAM1 gene is mapped to chromosome 14q23.1. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 4-6ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human skeletal muscle lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D0875-01C
Reactivities: Human, Mouse, Rat, Bovine, Canine
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Masami, Y. et al. Genes to Cells. 12:1255-1265 (2007). 2. Wei, L. et al. PNAS. 105:210-215 (2008). 3. Jun, L. et al. Journal of Molecular Biology. 369:1258-1269 (2007).
Additional info: Recognizes human DAAM1. Species Crossreactivity: bovine, canine, equine, mouse, rat.

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