DAAM1 (Disheveled-associated Activator of Morphogenesis 1, KIAA0666)

Supplier:

United States Biological

Cat no: D0875-01C

DAAM1 (Disheveled-associated Activator of Morphogenesis 1, KIAA0666)

DAAM1 is a diaphanous-related formin first studied as a novel Dishevelled binding protein and shown to be crucial for the planar cell polarity pathway in Xenopus. DAM1, like other formins, directs nucleation and elongation of new actin filaments using its conserved formin-homology-2 (FH2) domain. It is a Rho-regulated formin implicated in neuronal development and regulation of gastrulation. It was identified as a binding protein of the Wnt receptor-associated protein Dishevelled. It also binds the GTP-bound RhoA and increases its GTP-bound form population in cells. It exists in an autoinhibited state via intramolecular interactions between its amino-terminal GBD and carboxyl-terminalDD domains. Structurally the protein includes a GTPase-binding domain (GBD), a diaphanous inhibitory domain (DID), and a coiled-coil region followed by the FH1, FH2 and C-terminal diaphanous auto-regulatory domain (DAD). In humans, theDAM1 gene is mapped to chromosome 14q23.1.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 4-6ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman skeletal muscle lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

D0875-01C

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Bov, Can

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

1. Masami, Y. et al. Genes to Cells. 12:1255-1265 (2007). 2. Wei, L. et al. PNAS. 105:210-215 (2008). 3. Jun, L. et al. Journal of Molecular Biology. 369:1258-1269 (2007).

Additional Info

Recognizes human DAAM1. Species Crossreactivity: bovine, canine, equine, mouse, rat.

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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