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DAAM2 (Disheveled-associated Activator Of Morphogenesis 2, KIAA0381)

DAAM2 (Disheveled-associated Activator Of Morphogenesis 2, KIAA0381)

Cat no: D0875-02B

Supplier: United States Biological
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DAAM2 is a recently identified planar cell polarity (PCP) signaling molecule implicated in the regulation of cellular polarity, convergent extension, and invasion. DAM2 belongs to the formin homology family and contains aDD (diaphanous autoregulatory) domain, an FH1 (formin homology 1) domain, an FH2 (formin homology 2) domain and a GBD/FH3 (Rho GTPase-binding/ formin homology 3) domain. The DAM2 protein is known to be involved in cell divison. Though the exact function of DAM2 is yet unknown, reports suggest that it is closely related to DAM1 and hence along with DAM1 it may also be required in Wnt/Fz signaling and activation of Rho and in regulating cytoskeleton architecture. It is expressed in most of tissues but the expression level is higher in brain. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Skeletal muscle lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D0875-02B
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Habas, R. et al. Cell. 107:843-854 (2001). 2. Nagase, T. et al. DNA. Res. 4:141-150 (1997). 3. Katoh, Y. et al. Int. J. Mol. Med. 18:523-528 (2006).
Additional info: Recognizes human DAAM2. Species Crossreactivity: mouse.

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