DAAM2 (Disheveled-associated Activator Of Morphogenesis 2, KIAA0381)

DAAM2 is a recently identified planar cell polarity (PCP) signaling molecule implicated in the regulation of cellular polarity, convergent extension, and invasion. DAM2 belongs to the formin homology family and contains aDD (diaphanous autoregulatory) domain, an FH1 (formin homology 1) domain, an FH2 (formin homology 2) domain and a GBD/FH3 (Rho GTPase-binding/ formin homology 3) domain. The DAM2 protein is known to be involved in cell divison. Though the exact function of DAM2 is yet unknown, reports suggest that it is closely related to DAM1 and hence along with DAM1 it may also be required in Wnt/Fz signaling and activation of Rho and in regulating cytoskeleton architecture. It is expressed in most of tissues but the expression level is higher in brain.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.5-1ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nSkeletal muscle lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

D0875-02B

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Habas, R. et al. Cell. 107:843-854 (2001). 2. Nagase, T. et al. DNA. Res. 4:141-150 (1997). 3. Katoh, Y. et al. Int. J. Mol. Med. 18:523-528 (2006).

Additional Info

Recognizes human DAAM2. Species Crossreactivity: mouse.