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DACT1 (Dapper Homolog 1, hDPR1, Hepatocellular Carcinoma Novel Gene 3 Protein, DPR1, HNG3)

DACT1 (Dapper Homolog 1, hDPR1, Hepatocellular Carcinoma Novel Gene 3 Protein, DPR1, HNG3)

Cat no: D1055-02

Supplier: United States Biological
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DACT1 is a 836aa protein belonging to the Dapper family. It antagonizes Wnt signaling by promoting DVL2 (Dishevelled) degradation via a lysosome inhibitor-sensitive and proteasome inhibitor-insensitive mechanism and the interaction is formed between the DEP (Dishevelled, Egl-10, and pleckstrin) domain of Dvl and the central and C-terminal regions of DCT1. Wnt signaling plays a key role in embryogenesis and its dysregulation leads to cancer development. It binds to DVL2 and causes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway. DCT1 is required for normal notochord formation and is downregulated in hepatocellular carcinomas (HCC). It is expressed in liver and various other tissues. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D1055-02
Reactivities: Human, Non-Human Primate
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Zhang, L. et al. J. Biol. Chem. 281:8607-8612 (2006). 2. Yau, TO. et al. Oncogene. 24:1607-1614 (2005).
Additional info: Recognizes human DACT1. Species Crossreactivity: chimpanzee, monkey. Species sequence homology: chicken, mouse, opossum, rat.

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