DAPK2 (Death-associated Protein Kinase 2, DAP Kinase 2, DAP-kinase-related Protein 1, DRP-1)

Supplier:

United States Biological

Cat no: D1052-01H

DAPK2 (Death-associated Protein Kinase 2, DAP Kinase 2, DAP-kinase-related Protein 1, DRP-1)

Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DP kinase, are mediators of apoptosis. DP kinase (DAPK) is pro-apoptotic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DPK induces cell death and suppresses oncogenic transformation. DPK mediates IFNg induced apoptosis. A novel DP kinase-related protein was recently identified and designated DPK2 and DRP-1. Ectopicly expressed DPK2 induced apoptosis in various types of cells. DPK has high sequence homology to ZIP kinase and DRAK1/2, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. The messenger RNA of DPK2 is expressed in multiple human tissues.\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.5-1ug/ml\nImmunohistochemistry (paraffin): 2ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nA431 whole cell lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

D1052-01H

Size

50ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S. Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Oncogene 1999;18(23):3471-80 2. Inbal B, Shani G, Cohen O, Kissil JL, Kimchi A. Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis. Mol Cell Biol 2000;20(3):1044-54.

Additional Info

Recognizes human DAPK2. Species Crossreactivity: mouse and rat.

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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Reactivities

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