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DAPK2 (Death-associated Protein Kinase 2, DAP Kinase 2, DAP-kinase-related Protein 1, DRP-1)

DAPK2 (Death-associated Protein Kinase 2, DAP Kinase 2, DAP-kinase-related Protein 1, DRP-1)

Cat no: D1052-01J

Supplier: United States Biological
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Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DP kinase, are mediators of apoptosis. DP kinase (DAPK) is pro-apoptotic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DPK induces cell death and suppresses oncogenic transformation. DPK mediates IFNg induced apoptosis. A novel DP kinase-related protein was recently identified and designated DPK2 and DRP-1. Ectopicly expressed DPK2 induced apoptosis in various types of cells. DPK has high sequence homology to ZIP kinase and DRAK1/2, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. The messenger RNA of DPK2 is expressed in multiple human tissues. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Positive Control: Mouse brain Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D1052-01J
Reactivities: Mouse
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S. Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Oncogene 1999 Jun 10;18(23):3471-80 PMID: 10376525. 2. Inbal et.al Molecular and Cellular Biology 20 (3); 1044-1054 (February 2000). 3. G Shani et.al The EMBO Journal 20 (5); 1099-1113 (2001). 4. Inbal et.al The Journal of Cell Biology 157 (3); 455-468 (April 29, 2002).
Additional info: Recognizes mouse DAPK2. Species sequence homology: human.

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