Home  >  Products  >  DARPP32, phosphorylated (Thr34) (DARPP-32, Dopamine- and cAMP-regulated Neuronal Phosphoprotein, FLJ20940, Protein Phosphatase 1 Regulatory Subunit 1B, PPP1R1B)
DARPP32, phosphorylated (Thr34) (DARPP-32, Dopamine- and cAMP-regulated Neuronal Phosphoprotein, FLJ20940, Protein Phosphatase 1 Regulatory Subunit 1B, PPP1R1B)

DARPP32, phosphorylated (Thr34) (DARPP-32, Dopamine- and cAMP-regulated Neuronal Phosphoprotein, FLJ20940, Protein Phosphatase 1 Regulatory Subunit 1B, PPP1R1B)

Cat no: D1075-03B

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
DARPP-32, a dopamine (DA) and cAMP-regulated ~32kD phosphoprotein that is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac(R). Applications: Suitable for use in Western Blot.. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Positive Control: Forskolin incubated rat caduate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D1075-03B
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM HEPES (pH 7.5), 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B
References: 1. Fienberg, A.A., Hiroi, N., Mermelstein, P.G., Song, W., Snyder, G.L., Nishi, A., Cheramy, A., O'Callaghan, J.P., Miller, D.B., Cole, D.G., Corbett, R., Haile, C.N., Cooper, D.C., Onn, S.P., Grace, A.A., Ouimet, C.C., White, F.G., Hyman, S.E., Surmeier, D.G., Girault, J., Nestler, E.J. and Greengard, P.
Additional info: Recognizes human DARPP-32, phosphorylated at (Thr34). Species Crossreactivity: mouse and rat. Species Sequence Homology: bovine, chicken, canine and monkey.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave