Daxx is a novel regulator/modulator of apoptosis implicated in Fas- and TGF-b-induced apoptotic pathways. It was also found to be associated with PML protein in discrete nuclear structures known as PML oncogenic domains (PODs). Daxx as predominantly nuclear protein also functions as a repressor of Pax3 and Ets1 induced transactivation. Interestingly, in association with ASK1 kinase Daxx translocates from nuclei to cytoplasm. Though Daxx is thought to be mainly proapoptotic protein, extensive embryonic apoptosis in Daxx-deficient mice as well as its anti-apoptotic role in CD43-induced apoptosis suggest a promiscuous function of Daxx in the regulation of apoptosis.
Applications:
Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended Dilution:
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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