Daxx, CT, Blocking Peptide (BING2, DAP 6, DAP6, Death associated protein 6, EAP 1, EAP1, ETS1 associated protein 1, Fas death domain associated protein, hDaxx, MGC126245, MGC126246)

Peptide corresponding to amino acids 722 to 740 at C-terminus of human Daxx 1,2. \n\nApoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx1,2. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways (1,2).\n\nThis polyclonal antibody can be used for detection of Daxx by Western blot at 1:500 to 1:1000 dilution. HeLa whole cell lysate can be used as positive control and a 120kD major band can be detected. The sequences of immunogenic peptide are identical among human, monkey and mouse origins of Daxx1,2, and the antibody recognizes Daxx from all these species.

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SPECIFICATIONS

Catalog Number

D1150P

Size

50ug

Applications

WB

Form

Supplied as a lyophilized powder.

Purity

Purified 60-70%

References

1. Yang X, Khosravi-Far R, Chang HY, Baltimore D. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 1997;89:1067-1076. \n2. Kiriakidou M, Driscoll DA, Lopez-Guisa JM, Strauss JF 3rd. Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region. DNA Cell Biol 1997;16:1289-1298.\n3. Charette, S., et al., Mol. Cell Biol. 20:7602-7612, 2000\n4. Charette, S., et al., J. Biol. Chem. 276:36071-36074, 2001