DBZ (N-[(1S)-2-[[(7S)-6,7-Dihydro-5-meth yl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl -2-oxoethyl]-3,5-difluorobenzeneacetamide)

Solubility:\n100mM in DMSO\n\nMolecular Weight:\n~463.48\n\nBiological Activity:\nInhibitor of y-secretase. Blocks Notch cleavage (IC50< 2nm) in a cell-based assay; inhibits the Notch pathway.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

167642

Size

10mg

Form

Supplied as an off-white solid.

Purity

~98%

References

1. van Es et al (2005) Notch/g-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435 959. PMID: 15959515. 2. Groth et al (2010) Pharmacological analysis of Drosophila melanogaster g-secretase with respect to differential proteolysis of Notch and APP. Mol.Pharmacol. 77 567. PMID: 20064975.