DCAMKL1, NT (Serine/Threonine-protein Kinase DCLK1, Doublecortin-like And CAM Kinase-like 1, Doublecortin-like Kinase 1, Doublecortin Domain-containing Protein 3A, DCLK1, DCDC3A, KIAA0369) (APC)

Doublecortin-like kinase (DCAMKL1)(Ser/Thr protein kinase family) is essential for proper neurogenesis, neuronal migration, and axonal wiring. DCAMKL1 is involved in a calcium-signaling pathway controling neuronal migration in the developing brain, and participates in functions of the mature nervous system. DCAMKL1 protein shares high homology with doublecortin (DCX). DCLK, but not DCX, is highly expressed in regions of active neurogenesis in the neocortex and cerebellum. DCAMKL1 controls mitotic division by regulating spindle formation and also determines the fate of neural progenitors during cortical neurogenesis.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000 \nWestern Blot: 1:100-1:500\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

D1198-88-APC

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Allophycocyanin (APC).

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1.Matsumoto, N., et al., Genomics 56(2):179-183 (1999). 2.Sossey-Alaoui, K., et al., Genomics 56(1):121-126 (1999). 3.Omori, Y., et al., J. Hum. Genet. 43(3):169-177 (1998). 4.Nagase, T., et al., DNA Res. 4(2):141-150 (1997).

Additional Info

Recognizes human DCAMKL1. Species Crossreactivity: mouse.