Home  >  Products  >  DcR3, NT (Tumor Necrosis Factor Receptor Superfamily Member 6B, Decoy Receptor 3, DcR3, Decoy Receptor for Fas Ligand, M68, TNFRSF6B, TR6, UNQ186/PRO212)
DcR3, NT (Tumor Necrosis Factor Receptor Superfamily Member 6B, Decoy Receptor 3, DcR3, Decoy Receptor for Fas Ligand, M68, TNFRSF6B, TR6, UNQ186/PRO212)

DcR3, NT (Tumor Necrosis Factor Receptor Superfamily Member 6B, Decoy Receptor 3, DcR3, Decoy Receptor for Fas Ligand, M68, TNFRSF6B, TR6, UNQ186/PRO212)

Cat no: D1500-25Q

Supplier: United States Biological
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Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: Human heart (H), brain (B), and kidney (K) tissue lysates. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D1500-25Q
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Pitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, Donahue CJ, Sherwood SW, Baldwin DT, Godowski PJ, Wood WI, Gurney AL, Hillan KJ, Cohen RL, Goddard AD, Botstein D, Ashkenazi A. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature 1998;396:699-703. 2. Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J Biol Chem 1999;274:13733-6.
Additional info: Recognizes human DcR3. Species Crossreactivity: mouse and rat.

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