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Delta 4 (Delta-like Protein 4, DLL4, DLL-4, Drosophila Delta Homolog 4)

Delta 4 (Delta-like Protein 4, DLL4, DLL-4, Drosophila Delta Homolog 4)

Cat no: D2728-01E

Supplier: United States Biological
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Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Notch signaling is an evolutionarily conserved pathway that controls cell fate and is required in multiple developmental processes including vascular development, hematopoiesis, somatogenesis, myogenesis, and neurogenesis. Dysregulation in the Notch pathway is associated with various human diseases. In mammals, four Notch homologs (Notch 1 to 4) and five ligands (DLL 1, 3 and 4, Jagged 1 and 2) have been identified. Notch ligands are transmembrane proteins with a DSL motif necessary for Notch binding, tandem EGF repeats, a transmembrane region and a short intracellular domain (ICD). Notch ligands are categorized into two subfamilies based on the presence of an extracellular cysteine
Catalogue number: D2728-01E
Reactivities: Human, Mouse
Hosts: Rat
Applications: ELISA, Western Blot
Size: 500ug
Form: Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 1ml sterile PBS.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Shutter, J.R. et al. (2000) Genes Dev. 14:1313. 2. Iso, T. et al. (2002) Arterioscler. Thromb. Vasc. Biol. 23:543. 3. Walker, L. et al. (2001) Stem Cells 19:543. 4.Baron, M. (2002) Semin. Cell Dev. Biol. 14:113. 5. Ikeuchi, T. and S.S. Sisodia (2003) J. Biol. Chem. 278:7751. 6. Bland, C.E. et al. (2003) J. Biol. Chem. 278:13607.
Additional info: Recognizes mouse DLL4. Species Crossreactivity: human.

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