Dia1

Application(s): \nImmunoprecipitation (1:100)\nWestern Blot (1:1000-1:1

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SPECIFICATIONS

Catalog Number

D3250

Size

100ul

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum, Prc

Form

Liquid. Crude antiserum containing 0.01% sodium azide.

P Type

Pab

Purity

Serum

References

Product Specific Literature References\n1. The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins: M. Reinhard, et al.; EMBO J. 14, 1583 (1995)\n\nGENERAL LITERATURE REFERENCES\n[1] Diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene: D.H. Castrillon and S.A. Wasserman; Development 120, 3367 (1994) \n[2] p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin: N. Watanabe, et al.; EMBO J. 16, 3044 (1997) \n[3] Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling: T. Tominaga, et al.; Mol. Cell 5, 13 (2000) \n[4] Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous: E.D. Lynch, et al.; Science 278, 1315 (1997) \n[5] A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility: S. Bione, et al.; Am. J. Hum. Genet. 62, 533 (1998) \n[6] FH proteins as cytoskeletal organizers: S. Wasserman; TICB 8, 111 (1998)\n[7] Rho effectors and reorganization of actin cytoskeleton: S. Narumiya, et al.; FEBS Lett. 410, 68 (1997)\n[8] Cooperation between mDia1 and ROCK in Rho-induced actin reorganization: N. Watanabe, et al.; Nat. Cell Biol. 1, 136 (1999) \n[9] Distinct actions and cooperative roles of ROCK and mDia in Rho small G protein-induced reorganization of the actin cytoskeleton in Madin-Darby canine kidney cells: K. Nakano, et al.; Mol. Biol. Cell 10, 2481 (1999) \n[10] Stress fibres take shape: A.J. Ridley; Nat. Cell Biol. 1, E64 (1999)

Additional Info

Recognizes human and pig Dia1. Detects a band of ~81kDa by Western blot.