Digoxin

Digoxin also known as digitalis is a purified cardiac glycoside extracted from the foxglove plant, Digitalis lanata.[1] Its corresponding aglycone is digoxigenin, and its acetyl derivative is acetyldigoxin. Digoxin is widely used in the treatment of various heart conditions, namely atrial fibrillation, atrial flutter and sometimes heart failure that cannot be controlled by other medication. The main pharmacological effects of Digoxin are on the heart. Extra cardiac effects are responsible for many of the adverse effects (see below). It has mechanical effects as it increases myocardial contractility; however, the duration of the contractile response is just slightly increased. Overall, the heart rate is decreased, while blood pressure increases as the stroke volume is increased, leading to increased tissue perfusion. Myocardial efficiency improves due to improved hemodynamic, and the ventricular function curve is improved.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 0.625ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

D8030-11G

Size

100ul

Applications

ELISA

Hosts

Sheep

Form

Supplied as a liquid in 20mM phosphate, 150mM sodium chloride, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified

Isotype

IgG

References

1. A. Hollman (1996). \"Digoxin comes from Digitalis lanata\" (letter). British Medical Journal 312 (7035): 912. http://www.bmj.com/cgi/content/full/312/7035/912.

Additional Info

Recognizes digoxin.