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DISC1 (Disrupted in Schizophrenia 1, RP4-730B13.1, KIAA0457, SCZD9)

DISC1 (Disrupted in Schizophrenia 1, RP4-730B13.1, KIAA0457, SCZD9)

Cat no: D8066-83C

Supplier: United States Biological
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The DISC1 protein is widely expressed in normal tissues. It is involved in neurite outgrowth and cortical development through its interaction with a variety of proteins including lissencephaly-1 (LIS1), NudeE-like (NUDEL) and phosphodiesterase 4B. In certain cases of schizophrenia the DISC1 gene has been found to be disrupted by a t(1;11) (q42.1;q14.3) translocation, and studies suggest that DISC1 could be a candidate susceptibility gene for this condition. Applications: Suitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1-2ug/ml detects bands of approximately 95-100kD in SK-N-SH cell lysate. Immunocytochemistry: 5ug/ml Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D8066-83C
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
References: 1. Taya, S. et al. (2007) DISC1 regulates the transport of the NUDEL/LIS1/14-3-3eta complex through kinesin-1. J Neurosci. 27:15 - 26
Additional info: Recognizes disrupted in schizophrenia 1 (DISC1), 93kD protein located in the nucleus, cytoplasm and mitochondria. Species Crossreactivity: human and mouse

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