The DISC1 protein is widely expressed in normal tissues. It is involved in neurite outgrowth and
cortical development through its interaction with a variety of proteins including lissencephaly-1 (LIS1), NudeE- like (NUDEL) and phosphodiesterase 4B. DISC1 has been associated with the risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression and Asperger syndrome.
Applications:
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution:
Western Blot: 1-2ug/ml detects bands of approximately 95-100kD 3T3 in cell lysates.
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.