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DISC1 (Disrupted in Schizophrenia 1, RP4-730B13.1, KIAA0457, SCZD9)

Cat no: D8066-83D


Supplier: United States Biological
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The DISC1 protein is widely expressed in normal tissues. It is involved in neurite outgrowth and cortical development through its interaction with a variety of proteins including lissencephaly-1 (LIS1), NudeE- like (NUDEL) and phosphodiesterase 4B. DISC1 has been associated with the risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression and Asperger syndrome. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml detects bands of approximately 95-100kD 3T3 in cell lysates. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D8066-83D
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
References: 1. Taya, S. et al. (2007) DISC1 regulates the transport of the NUDEL/LIS1/14-3-3eta complex through kinesin-1. J Neurosci.27:15 - 26 2. Chubb, J.E. et al. (2008) The DISC locus in psychiatric illness. Mol Psychiatry.13:36 - 64.
Additional info: Recognizes disrupted in schizophrenia 1 (DISC1), 93kD protein located in the nucleus, cytoplasm and mitochondria. Species Crossreactivity: mouse

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