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DISC1 Polyclonal Antibody

Cat no: CAC08138

DISC1 Polyclonal Antibody

DISC1 Polyclonal Antibody

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SPECIFICATIONS

Price

323.00 USD

Catalog Number

CAC08138

Size

100 micro g

Applications

IF, WB

Hosts

Rabbit

Conjugates

Unconj

Purity

Protein G purified, >95%

Target

DISC1

Clonality

Polyclonal

Storage Temp

Aliquot and store at -20 degrees C. Minimize freezing and thawing.

Research Area

For research use only. Not for diagnostic procedures.

Shipping Temp

Blue ice

Additional Info

Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.

Alternative Names

Disrupted in schizophrenia 1 protein,DISC1,KIAA0457

SUPPLIER INFO

Biomatik Corporation

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