Home  >  Products  >  Dkk-1 (Dickkopf-1, DKK1, SK, hDKK-1, Dickkopf Homolog 1 (Xenopus laevis), Dickkopf-1 like, Dickkopf (Xenopus laevis) Homolog 1)
Dkk-1 (Dickkopf-1, DKK1, SK, hDKK-1, Dickkopf Homolog 1 (Xenopus laevis), Dickkopf-1 like, Dickkopf (Xenopus laevis) Homolog 1)

Dkk-1 (Dickkopf-1, DKK1, SK, hDKK-1, Dickkopf Homolog 1 (Xenopus laevis), Dickkopf-1 like, Dickkopf (Xenopus laevis) Homolog 1)

Cat no: D3810-01H

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
DKK1 inhibits Wnt signalling in embryonic development, most likely acting upstream of frizzled. It is also thought to contribute to neoplastic processes, inhibit osteoblast differentiation and is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Applications: Suitable for use in Immunohistochemistry (paraffin). Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 10ug/ml Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D3810-01H
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.7, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Krupnik, V. et al. (1999) Functional and structural diversity of the human Dickkopf gene family. Gene. 238:301-13. 2. Fedi, P. et al (1999) Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J. Biol. Chem. 274:19465-19472. 3. Niehrs C. (2006) Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene. 25:7469-81.
Additional info: Recognizes human Dickkopf (Xenopus laevis) homolog 1 (DKK1).

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave