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DKK1 (Dickkopf-related Protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, UNQ492/PRO1008)

DKK1 (Dickkopf-related Protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, UNQ492/PRO1008)

Cat no: D3810-01L

Supplier: United States Biological
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DKK1 is a 266aa secreted protein with two cysteine rich regions and belonging to the dickkopf family. It is involved in embryonic development through its inhibition of the WNT signaling pathway and in the reentry into the cell cycle of human adult stem cells from bone marrow. Its loss of expression plays a role in development or progression of malignant melanoma. DKK1 decreases melanocyte function and is a key player in multiple myeloma bone disease. It is a potential prognostic and diagnostic marker for breast cancer patients with poor prognosis. A high level of expression is found in the placenta. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D3810-01L
Reactivities: Human, Non-Human Primate
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Forget, MA. et al. Br. J. Cancer. 96:646-653 (2007). 2. Kuphal, S. et al. Oncogene. 25:5027-5036 (2006).
Additional info: Recognizes human DKK1. Species Crossreactivity: chimpanzee, monkey. Species sequence homology: bovine, equine, mouse, rat.

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