DKK2 (DKK2, SK, DKK-2, dickkopf homolog 2 (Xenopus laevis), dickkopf-2 like, dickkopf (Xenopus laevis) homolog 2)

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications have not been tested. \n\nRecommended Dilutions: \nPeptide ELISA Titer: 1:8000\nWestern Blot: 1-3ug/ml ~ 28kD band observed in Human Heart lysate (calculated MW of 28.5kD according to NP_055236).\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

D3795-03C

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by peptide affinity chromatography.

Isotype

IgG

References

1. Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA.\nFunctional and structural diversity of the human Dickkopf gene family.Gene. 1999 Oct 1;238(2):301-13.

Additional Info

Recognizes human DKK2. Species sequence homology: mouse, rat, canine, bovine.

Alternative Names

Dickkopf related protein-2, dickkopf homolog 2, dickkopf 2, dickkopf (Xenopus laevis) homolog 2, Dickkopf gene 2, DKK-2, dickkopf homolog 2 (Xenopus laevis), DKK2