DLG4, CT (Dlg4, Dlgh4, Psd95, Disks large homolog 4, Postsynaptic density protein 95, Synapse-associated protein 90)

a molecular scaffolding protein that binds and clusters N-methyl-D-aspartate receptors at neuronal synapses; may be involved in guanine nucleotide-mediated signal transduction pathway [RGD]\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, ELISA.\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100~500\nImmunohistochemistry: 1:50~100\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

030917

Size

100ul

Applications

ELISA, IHC, WB

Hosts

Mouse

Reactivities

Hum, Mouse

Form

Supplied as a liquid, crude ascites with 0.09% sodium azide.

P Type

Mab

Purity

Ascites

Isotype

IgM

References

SAP102 is a highly mobile MAGUK in spines. Zheng CY, et al. J Neurosci, 2010 Mar 31. PMID 20357126. Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. de Arce KP, et al. J Neurosci, 2010 Mar 10. PMID 20220006. Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia. Wang WW, et al. Brain Res, 2010 Apr 30. PMID 20197063. Hidden dynamic allostery in a PDZ domain. Petit CM, et al. Proc Natl Acad Sci U S A, 2009 Oct 27. PMID 19828436. Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation. Chen Q, et al. J Mol Neurosci, 2010 Mar. PMID 19629758.

Additional Info

Human, mouse

Alternative Names

Dlg4, Dlgh4, Psd95, Disks large homolog 4, Postsynaptic density protein 95, Synapse-associated protein 90