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DLL3 (Delta-like Protein 3, Drosophila Delta Homolog 3, Delta3)

DLL3 (Delta-like Protein 3, Drosophila Delta Homolog 3, Delta3)

Cat no: D2727-85A

Supplier: United States Biological
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Delta-like protein 3 is a ligand for the Notch signaling pathway. It inhibits primary neurogenesis. DLL3 plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Defects in DLL3 are the cause of Spondylocostal dysostosis autosomal recessive type 1 (SCDO1). Mutations in DLL3 gene cause truncal shortening relative to their limbs, which leads to abdominal protrusion, abnormal spinal curvature and sometimes a plagiocephaly-torticollis sequence. It may be required to divert neurons along a specific differentiation pathway. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 3-5ug/ml Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse embryo brain and T98G (human) cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D2727-85A
Reactivities: Human, Mouse, Non-Human Primate
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Bulman, MP. et al. Nat. Genet. 24:438-441 (2000). 2. Turnpenny, PD. et al. J. Med. Genet. 40:333-339 (2003). 3. Zhao, X. et al. Dev. Cell. 17:210-221 (2009).
Additional info: Recognizes human DLL3. Species Crossreactivity: monkey, mouse. Species sequence homology: bovine, canine, equine, rat.

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