DLX5 (distal-less homeobox 5) is a 33-35kD member of the distal-less homeobox family of transcription factors. It is expressed in embryonic mesenchyme where it promotes cartilage and bone formation, and in nervous tissue, where it promotes interneuron development. Human DLX5 is 289aa in length. It contains one DNA-binding homeobox domain (aa137-196), and two phosphorylation sites at aa34-217 that, when utilized, increases transcriptional activity. DLX5 likely forms homodimers, and is known to heterodimerize with MSX-2. Over aa216-289, human DLX5 shares 99aa identity with mouse DLX5.
Applications:
Suitable for use in Immunocytochemistry. Other applications not tested.
Recommended Dilution:
Immunocytochemistry: 5-15ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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