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DMAP1 (DNA Methyltransferase 1-Associated Protein 1, DNMAP1, DNMTAP1, DNMT1-Associated Protein 1, KIAA1425)

DMAP1 (DNA Methyltransferase 1-Associated Protein 1, DNMAP1, DNMTAP1, DNMT1-Associated Protein 1, KIAA1425)

Cat no: D8073-02F

Supplier: United States Biological
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DNA methyltransferase 1-associated protein (DMAP1) is found in a wide variety of living organisms from yeasts to humans. MMTR is a part of the basic cellular machinery for a wide range of transcriptional regulation via interaction with TFIIH and HDAC. DMAP1 is incorporated by Bmi1 in polycomb gene silencing. The DMAP1 gene works as a mutagen for tumor suppressor genes by causing hypermethylation and subsequent TA mutations of CpG islands. The direct role of Dnmt1 is restoration of epigenetic information during DNA repair. In eukaryotes the NuA4 histone acetyltransferase (HAT) complex is highly conserved and plays primary role in transcription, cellular response to DNA damage and cell cycle control. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D8073-02F
Reactivities: Human, Mouse, Rat, Bovine, Canine
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Kang, BG. et al. Mol. Cell. Biol. 27:3578-3588. (2007). 2. Negishi, M. et al. Biochem. Biophys. Res. Commun. 353:992-998 (2007).
Additional info: Recognizes human DMAP1. Species Crossreactivity: chimpanzee, bovine, canine, mouse, rat. Species sequence homology: pufferfish.

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