DMTF1, CT (DMTF1, DMP1, Cyclin-D-binding Myb-like transcription factor 1, Cyclin-D-interacting Myb-like protein 1) (AP)

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

034687-AP

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Alkaline Phosphatase.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Liu, Y., et al. Mol. Psychiatry (2010) In press :\nSugiyama, T., et al. Expert Rev. Mol. Diagn. 8(4):435-447(2008)\nInoue, K., et al. Cancer Res. 68(12):4487-4490(2008)\nTschan, M.P., et al. Leukemia 22(5):1087-1090(2008)\nMallakin, A., et al. Cancer Cell 12(4):381-394(2007)

Additional Info

Human

Alternative Names

DMTF1, DMP1, Cyclin-D-binding Myb-like transcription factor 1, Cyclin-D-interacting Myb-like protein 1