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DNA Methyltransferase 1 (DNMT, MCMT, M.Hsa1, DNA (cytosine-5-)-methyltransferase 1, DNA MTase Mmu1, M.HsaI)

DNA Methyltransferase 1 (DNMT, MCMT, M.Hsa1, DNA (cytosine-5-)-methyltransferase 1, DNA MTase Mmu1, M.HsaI)

Cat no: D3931-61J

Supplier: United States Biological
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Inactivation of tumor suppressor genes is a key component of the development of all common forms of human cancers. Aberrant methylation may contribute to many of the changes, both physiological and pathological, associated with aging, including tumor development. Hypermethylation of CpG island-containing promoters is associated with the inactivation of genes important to tumor angiogenesis and progression. DNA methytransferase (DNMT1) is necessary for the maintenance of the methylation process. Positive Control: T24 cell lysates. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D3931-61J
Reactivities: Human
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: As reported
P type: Pab
Purity: Serum
Alternative names: DNMT-1, DNMT, DNA (9cytosine-5-)-methylatransferase 1, MCMT, DNA MTase Mmu1, DNA methyltransferase M.HsaI
References: 1. Suzuki, H., et al. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nature. Doi:10.1038/ng892. 2. Bachman, K., et al. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell. 3:89-95, 2003. (Chromatin Immunoprecipitation, human) 3. Vertino, P., et al. De Novo Methylation of CpG Island Sequences in Human Fibroblasts Overexpressing DNA (Cytosine-5-)- Methyltransferase. Molecular and Cellular Biology.16(8):4555-4565, 1996. (Western blot, Immunohistochemistry, human) 4. Neumeister, P., et al. Senescence and epigenetic dysregulation in cancer. Int. J. Biochem. & Cell Biol. 34:1475-1490, 2002. 5. Yang, X., et al. Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression. Current Opinion in Genetics & Development. 13:1-11, 2003.
Additional info: This antibody is specific for DNMT1. Species Crossreactivity: Recognizes human. Other species have not been tested.

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