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DNA Methyltransferase 2 (DMNT2, DNMT2, DNA Methyltransferase Homolog HsaIIP, M.HsaIIP, PuMet, RNMT1, tRNA Aspartic Acid Methyltransferase 1, TRDMT1)

DNA Methyltransferase 2 (DMNT2, DNMT2, DNA Methyltransferase Homolog HsaIIP, M.HsaIIP, PuMet, RNMT1, tRNA Aspartic Acid Methyltransferase 1, TRDMT1)

Cat no: D3931-62E

Supplier: United States Biological
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Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. Dnmt2 contains all the sequence motifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the large N-terminal regulatory domain common to other eukaryotic methyltransferases. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D3931-62E
Reactivities: Mouse
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Mab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
Additional info: Recognizes mouse TRDMT1. Species sequence homology: human

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