Home  >  Products  >  DNA PK, Catalytic Subunit, phosphorylated (Thr2609) (DNA-dependent Protein Kinase)
DNA PK, Catalytic Subunit, phosphorylated (Thr2609) (DNA-dependent Protein Kinase)

DNA PK, Catalytic Subunit, phosphorylated (Thr2609) (DNA-dependent Protein Kinase)

Cat no: D3949-01G

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
DNA-protein kinase catalytic subunit (DNA-PKcs) also known as DNA-activated kinase is a nuclear 460-470kD serine threonine kinase involved in double-stranded DNA break repair, VDJ recombination, and transcriptional modulation. DNA-PKcs must bind DNA ends to become active. DNA-PKcs is modified by phosphorylation and has been shown to interact with Ku70/Ku80, KIP, DNA-ligase IV, and XRCC4 proteins. Phosphorylated DNA-PKcs is upregulated after DNA damage. Applications: Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Cellular Localization: Nuclear Positive Control: MOLT4 nuclear extract treated with 2 to 10 Gy radiation. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D3949-01G
Reactivities: Human
Hosts: Mouse
Applications: Immunofluorescence, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, containing 0.09% sodium azide
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography
Alternative names: DNAPK, DNAPK1, DNA-PKcs, DNA-Dependent Protein Kinase, catalytic subunit, PRKDC, Protein Kinase, DNA-activated, catalytic subunit, HYRC, HYRC1, Hyper-Radiosensitivity Complementing 1, XRCC7, X-ray Repair Complementing Defective Repair in Chinese Hamster Cells 7, p350, p460
References: 1. Hartley, K., et al., 1995. Cell. 82:849.2. Connelly, M., et al., 1996. Gene. 175:271.3. Douglas, P., et al., 2002. Biochem. J. 368:2434. Calsou, P., et al., 2003. J. Mol. Biol. 326:93.
Additional info: Recognizes human DNA PK catalytic subunit phosphorylated at Thr2609.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave