DNAJC2, ID (DNAJC2, MPHOSPH11, MPP11, ZRF1, DnaJ homolog subfamily C member 2, M-phase phosphoprotein 11, Zuotin-related factor 1) (PE)

This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

034714-PE

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Hatzold, J., et al. PLoS Biol. 6 (4), E84 (2008) :\nOlsen, J.V., et al. Cell 127(3):635-648(2006)\nOtto, H., et al. Proc. Natl. Acad. Sci. U.S.A. 102(29):10064-10069(2005)

Additional Info

Human, mouse

Alternative Names

DNAJC2, MPHOSPH11, MPP11, ZRF1, DnaJ homolog subfamily C member 2, M-phase phosphoprotein 11, Zuotin-related factor 1