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Dnmt3a (DNA (Cytosine-5)-methyltransferase 3A, DNA Methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, DNMT3A)

Dnmt3a (DNA (Cytosine-5)-methyltransferase 3A, DNA Methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, DNMT3A)

Cat no: D3931-70S

Supplier: United States Biological
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Dnmt3a, also known as DNA (cytosine-5)-methyltransferase 3A, is a nuclear protein belonging to the C5-methyltransferase family with an ADD-type zinc finger and a PWWP domain. This nuclear protein localizes to euchromatin and is essential for genome wide de novo methylation and is also essential for development. DNA methylation is coordinated with methylation of histones. Dnmt3a associates with HDAC1 through its ADD-type zinc-finger. It binds to the ZNF238 transcriptional repressor and is also known to interact with other DNA methyltransferases like Dnmt1 and Dnmt3b. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Dnmt3a transfected cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D3931-70S
Reactivities: Human, Non-Human Primate
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Chen, T. et al. J. Biol. Chem. 277:38746-38754 (2002). 2. Schlesinger, Y. et al. Nat. Genet. 39:232-236 (2007). 3. Li H. et al. J. Biol. Chem. 281:19489-19500 (2006).
Additional info: Recognizes human Dnmt3a. Species Crossreactivity: chimpanzee, rhesus monkey. Species sequence homology: feline, bovine, equine, mouse, rat.

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