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DNMT3B Polyclonal Antibody

Cat no: CAC07176

DNMT3B Polyclonal Antibody

DNMT3B Polyclonal Antibody

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SPECIFICATIONS

Price

323.00 USD

Catalog Number

CAC07176

Size

100 micro g

Applications

IHC, WB

Hosts

Rabbit

Conjugates

Unconj

Purity

Protein G purified, >95%

Target

DNMT3B

Clonality

Polyclonal

Storage Temp

Aliquot and store at -20 degrees C. Minimize freezing and thawing.

Research Area

For research use only. Not for diagnostic procedures.

Shipping Temp

Blue ice

Additional Info

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.

Alternative Names

DNA (cytosine-5)-methyltransferase 3B,DNA methyltransferase HsaIIIB,DNA MTase HsaIIIB,M.HsaIIIB,DNMT3B

SUPPLIER INFO

Biomatik Corporation

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