Docetaxel (Taxotere)

Cat no: D8077-02

Supplier: United States Biological

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An antineoplastic. An antimitotic agent that promotes the assembly of microtublules and inhibits their depolymerization to free tubulin. Melting Point: As reported Solubility: Soluble in DMSO at 200mg/ml. Soluble in ethanol at 100mg/ml. Very poorly soluble in water. Maximum solubility in plain water is estimated to be about 10-20uM. Elemental Analysis: Calculated: C 62.19% H 6.74% N 1.69% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.States Biological carry the condition that liability for any injury, loss or damage whatsoever to persons or real property resulting from the handling of the said goods lies with the user. Acceptance of our goods binds the customer to these terms.

Catalogue number:	D8077-02
Size:	100mg
Form:	As reported
Purity:	~90% (HPLC, TLC)
Alternative names:	Taxotere;
References:	Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993). Pienta, K.J. "Preclinical mechanisms of action of docetaxel and docetaxel combinations in prostate cancer." Semin Oncol. 4: 3-7 (2001). Yoshida, K., et al. "Phase I study of combination therapy with S-1 and docetaxel (TXT) for advanced or recurrent gastric cancer." Anticancer Res. 24: 1843-1851 (2004). Tabernero, J., et al. "A multicentre, randomised phase II study of weekly or 3-weekly docetaxel in patients with metastatic breast cancer." Ann Oncol. 15: 1358-1365 (2004).

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Docetaxel (Taxotere)

Cat no: D8077-02

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