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DOK1, phosphorylated (Tyr398) (Docking Protein 1, Downstream of Tyrosine Kinase 1, p62(dok), pp62)

DOK1, phosphorylated (Tyr398) (Docking Protein 1, Downstream of Tyrosine Kinase 1, p62(dok), pp62)

Cat no: D8080-01S

Supplier: United States Biological
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p62Dok was first identified as a 62kD RasGAP-binding protein in v-Abl transformed B cells and in Bcr-Abl expressing cells. It is a novel protein with features of a signaling molecule. Association of p62Dok with GAP correlates with its tyrosine phosphorylation. It is rapidly tyrosine-phosphorylated upon activation of the c-Kit receptor, implicating it as a component of a signal transduction pathway downstream of receptor tyrosine kinases. The protein contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Thefunctional role of the protein is implicated in the regulation of a wide range of physiological responses, including negative regulation of cytokines, enhanced cell migration, filopodia extension and tumor suppression. The adapter protein also plays distinct roles in mediating platelet activation in hemostasis. Human p62Dok gene maps on chromosome 2 at 2p13. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: K562 cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D8080-01S
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Carpino, N. et al. Cell. 88:197-204 (1997). 2. Antonio, C. et al. J. Biol. Chem. 273:4827-4830 (1998).
Additional info: Recognizes human p62Dok, phosphorylated at Tyr398. Species Crossreactivity: mouse and rat.

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