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Dopamine Decarboxylase (DOPA Decarboxylase, DDC, DOPA, Aromatic-L-amino-acid Decarboxylase, AADC)

Cat no: D9013-01L


Supplier: United States Biological
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DOPA Decarboxylase (aromatic L-amino acid decarboxylase, AADC; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002; Berry et al., 1996; Haycock et al., 2003). It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson
Catalogue number: D9013-01L
Reactivities: Human, Rat, Bovine, Canine, Guinea Pig, Porcine, Sheep
Hosts: Sheep
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid 10mM HEPES, pH 7.5, 150mM sodium chloride, 100ug per ml BSA, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Dopa Decarboxylase (Aromatic L-amino Acid Decarboxylase), EC=4.1.1.28
References: 1. Berry MD, Juorio AV, Li XM, Boulton AA (1996) Aromatic L-amino acid decarboxylase: a neglected andmisunderstood enzyme. Neurochem Res 21:1075-1087. 2. Haycock JW, Becker L, Ang L, Furukawa Y, Hornykiewicz O, Kish SJ (2003) Marked disparity between age-relatedchanges in dopamine and other presynaptic dopaminergic markers in human striatum. J Neurochem 87:574-585. 3. Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001)Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567. 4. Waymire JC, Haycock JW (2002) Lack of regulation of aromatic L-amino acid decarboxylase in intact bovinechromaffin cells. J Neurochem 81:589-593. 5. Zhu MY, Klimek V, Haycock JW, Ordway GA (2000) Quantitation of tyrosine hydroxylase protein in the locuscoeruleus from postmortem human brain. J Neurosci Meth 99:37-44. 6. Zhu MY, Klimek V, Dilley GE, Haycock JW, Stockmeier C, Overholser JC, Meltzer HY, Ordway GA (1999) Elevatedlevels of tyrosine hydroxylase in the locus coeruleus in major depression. Biol Psychiatry 46:1275-1286.
Additional info: Recognizes human DOPA Decarboxylase. Species crossreactivity: bovine, canine, porcine and rat.

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