Dopamine Decarboxylase (DOPA Decarboxylase, DDC, DOPA, Aromatic-L-amino-acid Decarboxylase, AADC)

DOPA Decarboxylase (aromatic L-amino acid decarboxylase, AADC; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002; Berry et al., 1996; Haycock et al., 2003). It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson

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SPECIFICATIONS

Catalog Number

D9013-01L

Size

100ul

Applications

WB

Hosts

Sheep

Reactivities

Hum, Rat, Bov, Can, GP, Prc, Sheep

Form

Supplied as a liquid 10mM HEPES, pH 7.5, 150mM sodium chloride, 100ug per ml BSA, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Berry MD, Juorio AV, Li XM, Boulton AA (1996) Aromatic L-amino acid decarboxylase: a neglected andmisunderstood enzyme. Neurochem Res 21:1075-1087. 2. Haycock JW, Becker L, Ang L, Furukawa Y, Hornykiewicz O, Kish SJ (2003) Marked disparity between age-relatedchanges in dopamine and other presynaptic dopaminergic markers in human striatum. J Neurochem 87:574-585. 3. Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001)Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567. 4. Waymire JC, Haycock JW (2002) Lack of regulation of aromatic L-amino acid decarboxylase in intact bovinechromaffin cells. J Neurochem 81:589-593. 5. Zhu MY, Klimek V, Haycock JW, Ordway GA (2000) Quantitation of tyrosine hydroxylase protein in the locuscoeruleus from postmortem human brain. J Neurosci Meth 99:37-44. 6. Zhu MY, Klimek V, Dilley GE, Haycock JW, Stockmeier C, Overholser JC, Meltzer HY, Ordway GA (1999) Elevatedlevels of tyrosine hydroxylase in the locus coeruleus in major depression. Biol Psychiatry 46:1275-1286.

Additional Info

Recognizes human DOPA Decarboxylase. Species crossreactivity: bovine, canine, porcine and rat.

Alternative Names

Dopa Decarboxylase (Aromatic L-amino Acid Decarboxylase), EC=4.1.1.28