Dopamine Receptor, D1b (D5)

The members of the G protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin, and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. Beta-adrenergic receptor bound to adrenaline activates adenylyl cyclase, while alpha 2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. The dopamine receptors are divided into two classes; D1 and D2, which differ in their functional characteristics. D1 receptors stimulate adenylyl cyclase, while D2 receptors inhibit adenylyl cyclase activity. Five different subtypes of dopamine receptor have been described to date. D1DR and D5DR belong to the D1 subclass, while D2DR, D3DR and D4DR belong to the D2 subclass of dopamine receptors.\n\nCellular Localization: Cell membrane; Multi-pass membrane protein. \n\nPositive Control: Sf9 cell lysates.\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

D9015-01

Size

100ul

Applications

WB

Hosts

Mouse

Reactivities

Rat

Form

Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1,k

References

1. 1. Luedtke, R et al. J. of Neuroimmuno. 101 :170-187 (1999)

Additional Info

This antibody reacts with Dopamine Receptor D1B. Species Crossreactivity: This antibody reacts with rat protein. Reactivity with mouse protein has had mixed results. It does not react with human protein. Other species have not been tested.

Alternative Names

D(1B) Dopamine Receptor, D(5) Dopamine Receptor, Drd5