Dopamine Receptor, D2, aa272-282

The DRD2 Dopamine Receptor is involved in the neuromodulation of appetitive behaviors. DRD2 may be linked to alcoholism and other substance-use disorders. Mutations in DRD2 in mice lead to the suppression of reward behavior with morphine and to the reduction of spontaneous movements, a phenotype resembling Parkinson's disease. Three alternatively spliced isoforms have been identified. DRD2 has been reported to be expressed in various regions of the brain, as well as in aorta, artery, eye, and spinal cord. ESTs have been isolated from normal pituitary and in brain, colon, lung, pancreas, and skeletal muscle cancer libraries.\n\nApplications: \nSuitable for use in Immunocytochemistry, Western Blot and ELISA. Other applications not tested. \n\nRecommended Dilutions: \nImmunocytochemistry: 1:5000\nWestern Blot: 1:800\nOptimal dilution determined by the researcher. \n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS, 10mg/ml BSA. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

D9000-03

Size

100ul

Applications

ELISA, ICC, WB

Hosts

Rabbit

Form

Supplied as a lyophilized powder. Reconstitute with 100ul sterile PBS, 10mg/ml BSA.

P Type

Pab

Purity

Serum

Isotype

IgG

Additional Info

Specific for D2 Dopamine Receptor (272-282). Detects two bands at ~48kD and ~51kD. \nCrossreactivity: D2s Dopamine Receptor: 70%; D2L Dopamine Receptor: 60%; D1 Dopamine Receptor (9-21), D1 Dopamine Receptor, D3 Dopamine Receptor (2-10), D3 Dopamine Receptor, D4 Dopamine Receptor (176-185), D4 Dopamine Receptor, D5 Dopamine Receptor (23-35), D5 Dopamine Receptor: 0%