Dopamine Receptor, D4 (D4R)

Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intracellular ion transport. A family of at least 5 Dopamine Receptors (DR) genes, D1-D5, have been identified based upon the amino acid identity, pharmacological specificity and effector responses. DR have been classified into either the D1-like (D1, D1B and D5) or D2-like (D2, D3 and D4). The two isoforms of D2R, D2 long (D2L) and short (D2S), are encoded by splice variants of a single gene and differ only by the presence of an additional 29aa in the intracellular domain 3 of the D2 long form. It may play a role in the coupling of the receptor to G-proteins. All members of this family have similar structure and contain 7 putative transmembrane domains. A given cell or tissue may express more than one DR. Specific radioligands do not exist that can differentiate between these DR. Therefore, specific antibodies are needed to distinguish, localize, and document changes in DR levels in cells and tissues under various normal and pathological conditions. Dopamine D4 Receptor is a 467aa, G-protein coupled and transmembrane receptor protein.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nWestern Blot: 1:1000-1:5000 (ECL). \nELISA: 1:10,000-1:50,000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

D9018-28

Size

50ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.05% sodium azide

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Van Tol, H.H., et al., Nature 358: 149-152 (1992). 2. Van Tol, H.H., et al., Nature 350: 610-614 (1992). 3. Livingstone, C.D., et al., Biochem. J. 287: 277-282 (1992). 4. Seeman, P., et al., Am. J. Med. Gentet. 54: 384-390 (1994). 5. O'Malley, K.L., et al., New Biol. 4: 137-146 (1992). 6. Fishburn, C.S., et al., FEBS Lett. 361: 215-219 (1995).

Additional Info

Recognizes human D4R. No significant sequence homology with other dopamine receptors (D1, D2, D3 or D5).