Home  >  Products  >  DOT1L (KMT4, Histone-lysine N-methyltransferase, H3 Lysine-79 Specific, Histone H3-K79 Methyltransferase, H3-K79-HMTase, DOT1-like Protein, Lysine N-methyltransferase 4, KIAA1814)
DOT1L (KMT4, Histone-lysine N-methyltransferase, H3 Lysine-79 Specific, Histone H3-K79 Methyltransferase, H3-K79-HMTase, DOT1-like Protein, Lysine N-methyltransferase 4, KIAA1814)

DOT1L (KMT4, Histone-lysine N-methyltransferase, H3 Lysine-79 Specific, Histone H3-K79 Methyltransferase, H3-K79-HMTase, DOT1-like Protein, Lysine N-methyltransferase 4, KIAA1814)

Cat no: D9056-01F

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
DOT1L is an evolutionarily conserved histone methyltransferase which methylates lysine 79 of histone H3 in the core domain. Unlike other histone methyltransferases, the protein does not contain a SET domain, an evolutionary conserved motif, and it specifically methylates nucleosomal histone H3. The protein was originally identified in S. cerevisiae as a disruptor of telomeric silencing. Analysis of the protein sequence revealed no known functional motif other than a putative SAM binding domain. Recent reports also suggests that the protein interacts with AF10, a mixed lineage leukemia fusion partner involved in acute myeloid leukemia, which results in leukemic transformation in a DOT1L methyltransferase activity-dependent manner. Human DOT1L gene is localized in the chromosomal region 19p13.3. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D9056-01F
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Jinrong, M. et al. Cell. 112:711-723 (2003). 2. Okada, Y. et al. Cell. 121:809-811 (2005). 3. Feng, Q. et al. Current Biology. 12:1052-1058 (2002).
Additional info: Recognizes human DOT1L. Species sequence homology: mouse.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave